Physics, Chemistry and Biology: Post your doubts here!

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When an injury causes a blood vessel wall to break, platelets are activated. They change shape from round to spiny, stick to the broken vessel wall and each other, and begin to plug the break.


The platelets also interact with fibrinogen, a soluble plasma protein, to form insoluble fibrin. Calcium is required for that.

Fibrin strands form a net that entraps more platelets and other blood cells (red cells and white cells), producing a clot that plugs the break.
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