The process of phagocytosis:
1. In the tissues attacked by pathogens mast cells produce histamine which causes inflammation and attract neutrophils.
2. Iflammation means that blood vessels dilate so more blood reaches site of attack and making capillaries leaky so phagocytes can ne squeezed out.
3. Neutrophils attracted towards the antigens by chemotaxis
4. Bacteria may be attracted directly to the membrane of neutrophil or marked by an antibody or plasma protein as the surface of neutrophil contains receptors for antibodies and plasma protein where they can be fiitted to stimulate the process of phagocytosis. (plasma protein used in marking antigen in known as complement or opsonin protein)
5. Pathogen is engulfed and taken in a vesicle by endocytosis.
6. Lysosomes fuse with the phagocytotic vesicle where bacteria are killed by free radicals, H2O2 and digested by enzymes.
The process of phagocytosis:
Thankssss Tasneem
Can you also tell me if we have to write about macrophages and all in this?