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another question i am unable to answer!!
View attachment 5601
please give me the answer to this question
i mean does mRNA have stages after it leaves the nucleus and enters the cytoplasm of a cell????
ok this will cover up protein synthesis i.e transcription and translation which includes the role of mRNA as well.
In the nucleus part of a DNA molecule unwinds and unzips as the hydrogen bonds between the bases break. free activitated RNA nucleotides pair up with the exposed bases of one strand only. as the RNA nucleotides pair up with their complementary ones, their sugar phosphate groups are bonded together to form a sugar phosphate backbone. the new single stranded molecule which has formed is called messenger RNA. it leaves the nucleus via a pore in the nuclear envelope.
in the cytoplasm there are free amino acids and transfer RNA molecules. at one end of each tRNA molecule is a site to which an amino acid can bind. at the other end are three unpaired bases. the base triplet is called an anti codon. each tRNA molecule bonds with a particular amino acid, under the control of a specific enzyme and with energy from atp.
meanwhile, also in the cytoplasm, the mRNA molecule attaches to a ribosome. ribosome are made of ribosomal RNA and protein and contain a small and large subunit. the mRNA binds to the small subunit. six bases at a time are exposed to the large subunit.
the first three exposed bases, or codons are always AUG. A tRNA molecule with the complementary anticodon, UAC, forms hydrogen bonds with this codon.
a second trna molecule bonds with the next three exposed bases. this one brings a different amino aicd. the two amino acids are held closelty together, and a peptide bond is formed between them. this reaction is catalysed by the enzyme peptidyl transferase, which is found in the small subunit of the ribosome.
the ribosome now moves along the mRNA reading the next three bases on the ribosome. a third tRNA molecule brings a third amino acid, which joins to the second one. the first tRNA leaves.
the polypeptide chain continues to grow like a good baby until a stop codon is exposed on the ribosome. this is UAA, UAC OR UGA. reference to this info is from mary jones book.